Quality
COA, HPLC and batch documentation explained
What a Certificate of Analysis can and cannot prove, how HPLC purity is read and why batch numbers matter.
Compiled from batch documentation, COA/SDS checks and peer-reviewed literature. Content is intended as research-only technical documentation.
Important
Research Use Only. This information is intended for laboratory context and does not include dosing, administration advice, or claims for human or veterinary use.
What is on a COA?
A COA should at minimum show product name, batch number, test date, analytical method and result. For peptides this often covers identity and purity, for example via HPLC or mass spectrometry.
HPLC purity
HPLC separates components in a sample and reports relative peak areas. High HPLC purity says something about analytical purity within that method, but it does not replace correct storage or batch traceability.
Batch linkage
The batch number on the vial should match the COA. Without that link, a report is less useful for quality control.
Primary sources & literature
External literature and databases for checking claims, identity and analytical methods. Always verify batch-specific details against COA/SDS.
PubMed
Degradation pathways, analytical characterization and formulation strategies of a peptide and a protein
PubMed